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Sustainability has taken an increasingly strategic place in the roadmap of organizations across the globe. A highly effective and readily-available way to significantly improve the sustainability footprint of the petrochemical industry, as well as of the myriad sectors it serves, is the usage of non-fossil raw materials. In this paper, Neste and Linde discuss the drop-in nature of renewable hydrocarbons as petrochemical feedstock, with a focus on renewable naphtha and Hydrotreated Vegetable Oil (HVO). Based on a broad range of analysis and pilot cracking experiments and scenarios for site-optimization calculations, the benefits and points of attention for the successful utilization of renewable feedstocks are presented. The presentation aims at providing a good overall understanding of the opportunities, challenges and resources available to cracker operators (and downstream players) for the successful, commercial-scale implementation of this highly effective de-fossilization mechanism.